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Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology [Hardcover]

Item : Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology [Hardcover]
Price : $184.99 (see below)
Category : Books
ISBN-10 ISBN-10 : 3319283030
ISBN-13 ISBN-13 : 9783319283036
Publisher Publisher : Humana Press
Binding Binding : Hardcover
Item ID : 100106116

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. 

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. 


1 Introduction and Background

Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano

Part 1 From Bedside to Bench: Radiobiological Topics Arising from Clinical Studies

 

2 The Radio-resistance of Glioblastoma in the Clinical Setting and the Present Therapeutic Options

Michela Buglione, Luca Triggiani, Paolo Borghetti, Sara Pedretti, Nadia Pasinetti, Stefano Maria Magrini<lC†

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