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Principles Of Translational Science In Medicine: From Bench To Bedside [Hardcover]

Item : Principles Of Translational Science In Medicine: From Bench To Bedside [Hardcover]
Price : $125.99 (see below)
Category : Books
ISBN-10 ISBN-10 : 0521888697
ISBN-13 ISBN-13 : 9780521888691
Publisher Publisher : Cambridge University Press
Pages Pages : 404
Binding Binding : Hardcover
Item ID : 100012300

A state-of-the-art survey of translational medicine, with emphasis on its emerging scientific backbone, its strengths, and its weaknesses.This textbook will comprise a state-of-the-art survey of translational medicine, with emphasis on its emerging scientific backbone, its strengths, and its weaknesses. It explores all aspects of preclinical and clinical issues that are relevant to the success of translational pharmaceutical or medical device or diagnostic innovations and guides readers in designing smart profiling strategies for new approaches to the field.This textbook will comprise a state-of-the-art survey of translational medicine, with emphasis on its emerging scientific backbone, its strengths, and its weaknesses. It explores all aspects of preclinical and clinical issues that are relevant to the success of translational pharmaceutical or medical device or diagnostic innovations and guides readers in designing smart profiling strategies for new approaches to the field.Despite advancements in the cloning of the total human genome, biomedical innovations at the patient level are becoming rare events. However, translational medicine is a burgeoning science that shows the potential to reverse the trend. This textbook will comprise a state-of-the-art survey of translational medicine, with emphasis on its emerging scientific backbone, its strengths, and its weaknesses. It explores all aspects of preclinical and clinical issues that are relevant to the success of translational pharmaceutical or medical device or diagnostic innovations, including target risk assessment, biomarker evaluation, and predictivity grading for both efficacy and toxicity; early human trial designs that are adequate to guide stop or go decisions on the grounds of biomarker panels; and biostatistical methods to analyze multiple readout situations and quantify risk projections. The book provides guidance to design smart profiling strategies for new approaches aimed at cutting timelines and conlCÒ

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