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The Biological Chemistry of Nickel [Hardcover]

Item : The Biological Chemistry of Nickel [Hardcover]
Price : $286.99 (see below)
Category : Books
ISBN-10 ISBN-10 : 1782624988
ISBN-13 ISBN-13 : 9781782624981
Publisher Publisher : Royal Society of Chemistry
Pages Pages : 396
Binding Binding : Hardcover
Item ID : 100119950

Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects.

This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles).

Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance.

This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

Nickel is an essential element in many biochemical processes and there has been significant recent research into understanding the role this transition element plays. This book discusses a range of key topics in this field including the coordination chemistry of nickel-containing biomolecules, current theories on nickel-containing enzymes and the transport, storage and transcriptional regulation of nickel in biological systems. An essential text for biochemists, biologists and medicinal chemists, this book provides a comprehensive review of the latest findings in nickel biology and chemisl√

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